肺癌患者血清VEGF、CoⅣ、LN检测及其临床意义

Detection and clinical significance of serum VEGF, CoⅣ and LN in patients with primary lung cancer

目的 讨论肺癌患者血清血管内皮生长因子 (Vascularendothelialgrowthfactor,VEGF)、Ⅳ型胶原 (TypeⅣcollage ,CoⅣ )、层粘蛋白 (Laminin ,LN)水平变化与肿瘤浸润转移的关系。方法 收集 34例肺癌患者及对照组 30例静脉血 ,采用酶联免疫法(ELISA)、放射免疫分析法 (RIA)检测血清中VEGF、CoⅣ、LN浓度。结果 肺癌组Ⅱ期以上患者血清VEGF、CoⅣ、LN较对照组显著升高 (P <0 .0 5 ) ,在肺癌组随着分期进展 ,VEGF、CoⅣ、LN水平逐渐升高 ,Ⅱ、Ⅲ、Ⅳ期组间比较有非常显著差异 (P <0 .0 1)。结论 VEGF、CoⅣ、LN与肿瘤浸润转移有关 ,可作为评价肿瘤患者疗效、判断病情。

Objective To investigate serum VEGF?CoⅣ?LN levels in patients with primary lung cancer and their relationship with cancer metastasis. Methods The concentrations of serum VEGF?CoⅣ?LN were measured by ELISA?RIA respectively in 34 patients with primary lung cancer. Other 30 people with no mirnany lung cancer served as controls. Results Significant differences in the VEGF?CoⅣ?LN level were observed between controls and the patients with lung cancer Ⅱ stage( P <0.05). The VEGF?CoⅣ?LN significantly increased in patients with lung cancer Ⅱ? Ⅲ? Ⅳ stages ( P <0.01). Conclusion The VEGF?CoⅣ?LN levels may be helpful for indicating states of the disease, predicting the prognosis, and the assistant treatment for patients with primary lung cancer.