深低温保存羊膜在结膜重建中的临床应用

Preserved human amniotic membrane transplantation for conjunctival reconstruction

目的 :分析深低温保存羊膜移植重建结膜手术成功的基本条件和具体手术方法 ,评价手术疗效。方法 :用深低温保存的羊膜治疗 43例结膜损伤患者。包括无眼球结膜囊狭窄 10例 ,大面积结膜肿瘤 13例 ,睑球粘连 9例 ,翼状胬肉 7例 ,并尝试对少数 ( 4例 )义眼座暴露病例进行羊膜修补。结果 :随诊 6～ 18个月 ,总治愈率达 88 6 4% ,无眼球结膜囊狭窄的治愈率为 80 % ,睑球粘连的治愈率达 88 89% ,大面积结膜肿瘤和复发性胬肉的治愈率皆为 10 0 % ,而应用深低温保存羊膜修补义眼座暴露 ,治愈率只有 5 0 %。结论 :深低温保存羊膜移植重建结膜手术成功的基本条件是受体眼有一定量的健康结膜。

Objective:To analyze the main conditions and the operational procedure of preserved human amniotic membrane transplantation for conjunctival reconstruction,and to evaluate the curative effects. Methods:43 consecutive patients who underwent preserved amniotic membrane transplantation were included,10 patients with conjunctival sac constriction,13 patients with large conjunctival tumor,9 patients with symblepharon,7 patients with recurrent pterygium and 4 patients with orbital implants exposure. Results:39 cases had satisfactory curative effect(88 86%)during the follow up of 6～18 months,including 8 patients with conjunctival sac constriction,13 patients with large conjunctival tumor,8 patients with symblepharon,7 patients with recurrent pterygium and 2 patients with orbital implants exposure. Conclusions:An amount of healthy conjunctiva on the receptor is the main condition of preserved human amniotic membrane transplantation.