前房内注射去甲万古霉素对预防超声乳化术后感染的作用

Intracameral vancomycin in the prevention from infectious endophthalmitis on phacoemulsification with intraocular lens

目的 :观察前房内注射去甲万古霉素对预防白内障超声乳化摘除术后感染性眼内炎的作用。方法 :回顾本院 1997年 1月以来所施行的 15 5 2 0眼白内障超声乳化摘除联合人工晶体植入术 ,其中术中未在前房注射去甲万古霉素者 832 2眼 ,术中前房内注射去甲万古霉素者 7198眼。注射药物的方法为在白内障超声乳化摘除联合人工晶体植入术毕向前房内注射盐酸去甲万古霉素 0 4～ 0 8mg。记录并比较两组病例感染性眼内炎的发生率。结果 :随访时间 0 5～ 32个月。未注射药物组共有 5例 ( 5眼 )发生感染性眼内炎 ( 0 0 6 % ) ,其中细菌性眼内炎 4眼( 0 0 5 % ) ,真菌性眼内炎 1眼 ;注射药物组尚未发现感染性眼内炎的病例。结论

Objective:To observe the effect of intracameral injection of norvancomycin in the prevention of bacterial endophthalmitis after phacoemulsification with intraocular lens(IOL)implantation. Methods:In 15520 eyes of cataract had undergone phacoemulsification with IOL implantation,8322 eyes(No Injection Group)had not been given intracameral injection of norvancomycin,but 7198 eyes(Injection Group)had been given intracameral injection of 0 4～0 8mg norvancomycin right after phacoemulsification with IOL implantation,Cases of postoperative infectious endophthalmitis were retrospected and compared between the two groups.Follow up was 0 5～32 months. Results:Five cases(5 eyes)of postoperative infectious endophthalmitis occurred in No Injection Group(0 06%),of which 4 eyes(0 05%)had bacterial endophthalmitis and one had fungal endophthalmitis.There was no postoperative endophthalmitis detected yet in Injection Group. Conclusions:Intracameral injection of norvancomycin seems effective in the prevention from postoperative bacterial endophthalmitis in phacoemulsification with IOL implantation.