鳞癌抗原在子宫颈鳞癌中的应用价值

The value of squamous cell carcinoma antigen in invasive squamous cell carcinoma of the cervix

目的 :探讨鳞癌抗原 (SCCAg)在子宫颈鳞癌中的临床应用价值。方法 :微粒子酶免法检测 12 4例子宫颈鳞癌患者治疗前血清SCCAg值 ,对照组 180例为妇科良性疾病患者。早期患者 (Ⅰ～Ⅱa期 )术后一周重复检测SCCAg值 ,部分根治手术患者随诊中监测。结果 :SCCAg在子宫颈鳞癌中的敏感性为 73.4% ,特异性为 96 .1%。SCCAg阳性率随临床分期进展而增高 ,差异有显著性 (P <0 .0 0 5 ) ,早期患者 (Ⅰ期和Ⅱa期 )术前SCCAg值异常者术后均下降至正常水平 ,差异均有显著性 (P <0 .0 0 1)。部分术后患者在 3年随访期内血清SCCAg值在正常水平。结论 :SCCAg是子宫颈鳞癌较特异的肿瘤标志物 ,可以作为子宫颈癌辅助诊断指标 ,评估子宫颈癌手术疗效 。

Objective:To explore the value of squamous cell carcinoma antigen(SCCAg) in patients with squamous cell carcinoma of the cervix. Methods:The serum concentraction of SCCAg in 124 patients with squamous cell carcinoma of the cervix and 180 patients with gynecologic benign diseases before treatment was determined by Micropatricle Enzyme Immunoassay(MEIA).The SCCAg of the early stage patients(Ⅰ～Ⅱa) was remeasured one week after radical surgery.The SCCAg in some patients was monitored during follow up.Results:The SCCAg levels in patients with squamous cell carcinoma of the cervix showed a sensitivity of 73.4% and a specificity of 96.1%.The SCCAg positive rates increased with elevation of clinical stage( P <0.005).The abnormal SCCAg levels of early stage patients(Ⅰand Ⅱa) before surgery decreased to normal one week after treatment with statistical significance( P <0.001).The SCCAg levels of some patients after surgery kept normal during follow up.Conclusions:SCCAg is a specific tumor marker of the squamous cell carcinoma of the cervix.The SCCAg can be used as a marker adjuvant diagnosis of cervical cancer and to estimate the surgical efficacy.The clinical significance of SCCAg in early stage carcinoma of the cervix needs farther study.