介入手段实现的局部转导在肿瘤基因治疗系统中的应用
被引量:1
摘要
肿瘤的基因治疗主要包括自杀基因治疗、抑癌基因治疗、反义癌基因治疗和免疫基因治疗等,相应的载体可选用病毒类或非病毒类载体。在临床与研究中,介入手段实现的局部转导主要包括转基因载体的肿瘤瘤体内注射和经导管血管内灌注,具体手段的选择与治疗机理、载体以及肿瘤特性等多种因素相关。
参考文献23
-
1Vile RG, Rusell SJ, Lemoine NR. Cancer gene therapy: hard lesson and new course. Gene Ther ,2000,7(1) : 2-8
-
2Ray CE. Interventional radiology in cancer patient. Am Fam Physician ,2000, 62(1) : 95-102
-
3Libi W, Culver K, Walbridge S, et al. In vitro evidence that metabolic cooperation is response for the bystander effect observed with HSV- tk retroviral gene therapy. Hum Gene Ther , 1993, 4(6) : 725-731
-
4Baker SJ, Markowitz S, Fearon E, et al. Suppression of human colorectal carcinoma cell growth by wild type p53. Science, 1990,249(4971) : 912-915
-
5Odin L, Favrot M, Poujol D, et al. Canarypox virus expressing wild type p53 for gene therapy in murine tumors mutated in p53.Cancer Gene Therapy ,2001,8(2): 87-98
-
6Habib NA, Hodgson HJ, Lemoine N, et al. A phase Ⅰ/Ⅱ study of hepatic artery infusion with wtp53- CMV- Ad in metastatic malignant liver tumors. Hum Gene Ther, 1999, 10(12) : 2019-2034
-
7Steiner MS,Anthony CT, Lu Y, et al. Antisense e - Mye retroviral vector suppresses established human prostate cancer. Hum Gene Ther, 1998,9(5) : 747-755
-
8Eck SL, Alavi JB, Judy K, et al. Treatment of recurrent or progressive malignant glioma with a recombinant adenovirus expressing human interferon - beta(H5. 010CMVhIFN - β) : a phase Ⅰ trial. Hum Gene Ther, 2001,12(1) : 97-113
-
9Nemunaitis J, Cunningham C, Buchanan A, et al. Intravenous infusion of a replication - selective adenovirus (ONYX - 015) in cancer patients: safety, feasibility and biological activity. Gene Ther, 2001,8(10) : 746-759
-
10Bisehoff JR, Kim DH, Williams A, et al. An adenovirus, mutant that replicates selectively in p53 - deficient human tumor cells. Science, 1996, 274(5286) : 373-376
同被引文献20
-
1孙龙,官泳松,周翔平,李肖.介入放射学在肿瘤基因治疗中的意义[J].中国介入影像与治疗学,2004,1(2):151-154. 被引量:7
-
2焦旭东,陈方满.肺癌介入治疗现状综述[J].华北煤炭医学院学报,2006,8(6):771-773. 被引量:1
-
3Mikaye M, Taki T, Hitomi S, et al. Correlation of expression of H/ Ley / Leb antigens with survival in patients with carcinoma of the lung [J]. N Engl J Med, 1992,327:14- 18.
-
4Reed JC. Bcl-2 and the regulation of programmed cell death[J]. J Cell Biol, 1994,124:1-5.
-
5Levine A. The p53 tumor-auppress or gene[J]. N Engl J Med, 1992, 326:1350 - 1352.
-
6Folkman J. What is the evidence that tumors are angiogenesis dependant? [J]. J Nall Caaeer Inst,1989,82:4-6.
-
7Hananhan D, Folkman J. Patterns and emerging mechanisms of the angiogenie switch during tumorigenesis[J]. CEU,1996,86:353-364.
-
8Shimizu E, Na kamura Y, Mukai J, et al. Pharmacokinetics of bronchial artery infusion of mitomycin in patients with non-small cell lung cancer[J].. Eur J Cancer, 1991,27:1046.
-
9Masuda H, Makita K, Nakajima T. Chest wall implanted reservoir for bronchial arterial infusion of antineoplastie agents in high-aged lung cancer patients[J]. Jpn J Thorae Cardiovasc Surg,1999,47:124.
-
10Liu ZL. Profess in interventional therapy of lung cancer[ J]. Journal of Postgraduates of Medicine, 2001,24:12.
二级引证文献10
-
1胡小波,曹建民,陈波,许健.肺癌介入治疗现状与进展[J].当代医学,2009,15(17):366-368. 被引量:20
-
2施长杲,吕维富.中晚期肺癌的介入治疗现状及进展[J].临床肺科杂志,2011,16(2):261-263. 被引量:5
-
3黄扬,朱宇峰,张兴仕.中晚期肺癌介入治疗的临床疗效分析[J].中外医学研究,2011,9(22):124-125. 被引量:10
-
4谢雯.肺癌介入治疗的应用与护理[J].求医问药(下半月刊),2011,9(10):103-103. 被引量:1
-
5曹慧娟,王文玉,孙淑军,戴建业,毛文伟,张永煜.肺癌基因治疗的方法[J].中华中医药学刊,2012,30(6):1354-1356.
-
6高国明,贾双琴.中晚期中央型肺癌微球超选择动脉栓塞疗效分析[J].甘肃医药,2012,31(7):509-512. 被引量:2
-
7王金英,张洪英.肺癌介入治疗的护理[J].中国医药指南,2012,10(20):601-603. 被引量:2
-
8陆月兰,高文君,李杉.肺癌介入治疗现状与护理研究进展[J].上海护理,2013,13(1):64-69. 被引量:6
-
9王瑞涛.原发性肺癌介入治疗的现状与进展[J].武警后勤学院学报(医学版),2013,22(11):1049-1052. 被引量:5
-
10赵真真,王忠敏,茅爱武.非小细胞肺癌的介入治疗现状[J].介入放射学杂志,2014,23(3):272-276. 被引量:45
-
1王建波,谢春明,刘起旺.肝癌介入治疗及其进展[J].山西医科大学学报,2000,31(6):550-552. 被引量:6
-
2于永江,范荣,王丽英,王德本,岳玲.亚段性经导管动脉化疗栓塞术治疗中晚期原发性肝癌的临床研究[J].介入放射学杂志,2002,11(5):348-350. 被引量:8
-
3齐丽萍,董志,丛培生,范新,杨笑宏.中、晚期肝癌介入治疗预后因素分析[J].中国临床医学影像杂志,2002,13(1):32-35. 被引量:3
-
4姚翀,武鑫,张丽娟,高申.非病毒类载体靶向治疗前列腺癌研究进展[J].第二军医大学学报,2015,36(8):888-892.
-
5薛耀勤,温树伟,畅俊平,黄慧.经导管动脉灌注化疗联合手术治疗直肠癌[J].山西医科大学学报,2009,40(8):747-748. 被引量:2
-
6苏国强,田建明,王永春.肾血管平滑肌脂肪瘤的DSA表现及介入治疗[J].医学影像学杂志,2001,11(6):388-389. 被引量:1
-
7许毛峰,于伟红,刘志文.食管恶性狭窄内支架姑息治疗及其并发症的处理[J].医学综述,2008,14(11):1740-1742.
-
8陈方满,杨文藻.经导管治疗肝恶性肿瘤[J].皖南医学院学报,1991,10(1):50-52.
-
9陆前进.恶性黑素瘤基因治疗的研究进展[J].国外医学(皮肤性病学分册),1997,23(6):329-331.
-
10沈裕康.肿瘤的基因治疗[J].上海医药,1999,20(9):11-13.