人类巨细胞病毒活动性感染与母婴垂直传播

Human Cytomegalovirus Active Infection and the Vertical Transmission

目的 :探讨孕妇人类巨细胞病毒 (HCMV)活动性感染与母婴垂直传播的关系。方法 :应用ELISA、PCR和RT PCR方法分别检测 117份、12 2份、2 5份妊娠妇女及其新生儿或流产物的HCMV IgM抗体、mRNA及DNA。HCMV IgM抗体或HCMV mRNA阳性的孕妇为HCMV活动性感染组 ,HCMV DNA阳性的孕妇为HCMV非活动性感染组。新生儿脐血 ,生后 1周内子尿、唾液HCMV阳性 ,或流产物阳性者为HCMV宫内感染。结果 :活动性感染孕妇组垂直传播率为 80 .0 0 % ,非活动性感染孕妇组垂直传播率为 17.4 0 % ,两者有显著性差异 (P <0 .0 1)。活动性感染孕妇垂直传播的相对危险度RR =19.0 0。结论 :HCMV活动性感染与母婴垂直传播密切相关 ,将HCMV

Objective: This paper was to explore the relationship between maternal human cytomegalovirus (HCMV) active infection during pregnancy and the risk of transmission to the fetus. Methods: Using ELISA,PCR and RT PCR assays ,we measured HCMV IgM,DNA or mRNA for 117,122 and 25 specimens respectively. Results: The rate of vertical transmission of HCMV in those active infectious pregnant women (80.00%) was significantly higher than that in those inactive infectious ones(17.40%) (P<0.01), and the RR is 19.00. Conclusion: HCMV active infection during pregnancy is related to vertical transmission. Detecting HCMV DNA as well as HCMV IgM and mRNA are probably an effective method to evaluate HCMV infection in pregnancy and the vertical transmission of HCMV.