纳催离和苯那普利治疗高血压合并糖尿病动态血压及微白蛋白尿的比较研究

Comparation of 24-h Ambulatory Blood Pressure and Urinary Microalbumin in Hypertension with Diabetes Treated with Natrilix and Benazepril

探讨纳催离 (吲哒帕胺 )治疗高血压 (HP)合并Ⅱ型糖尿病 (NIDDM )病人降压效应及对微量白蛋白(mAlb)尿的影响 ,并与苯那普利 (洛丁新 )的疗效相比较 .对HP合并NIDDM病人 4 6例给予纳催离以及 4 4例给予苯那普利治疗 6个月 ,进行用药前后 2 4h动态血压 (ABPM )及尿mAlb测定 .结果显示 :与对照组及自身对照相比 ,纳催离与苯那普利治疗后 ,ABPM指标及尿mAlb均显著改善 (P <0 0 5或P <0 0 1) ,而两药之间疗效对比无差异 .上述结果提示 :纳催离治疗HP合并NIDDM病人与苯那普利效果一样 ,明显降低血压的同时 。

The relationship between ABPM and MALB in hypertension patients with diabetes treated with natrilix and benazepril was discussed here. 46 hypertension patients with diabetes were given natrilix and 44 were given benapril for 6 months. ABPM and urinary MALB were examined before and after treatment. Compared with the self group and the control group, their indexes of ABPM and MALB were obviously improved (P<0 05 or P<0 01). The effectiveness of natrilix and benazepril was similar. Results showed natrilix and benazepril may reduce blood pressure and urinary microalbumin in hypertension patients with diabetes.