肺心病患者血中可溶性白细胞介素-2受体和T淋巴细胞亚群的变化及临床意义

The clinical value and change of slL-2R, CD4 and CD8 in patients with the chronic pulmonary heart disease

目的探讨慢性肺原性心脏病 (简称肺心病 )患者血中可溶性白细胞介素 - 2受体 (sIL- 2R)及T淋巴细胞亚群CD+ 4、CD+ 8的变化及临床意义。方法分别抽取 30例肺心病急性期及缓解期患者晨起空腹血检测sIL - 2R、CD+ 4及CD+ 8。结果肺心病急性期sIL - 2R水平明显增高 ,缓解期下降 ,但仍高于正常对照组。CD+ 4T淋巴细胞亚群在肺心病急性期及缓解期变化不明显 ,但急性期结果与正常对照组比较差异有统计学意义。CD+ 4/CD+ 8细胞的比值在急性期 <1。结论肺心病患者存在免疫调节功能异常 。

Objective To evaluate the clinical value and change of plasma slL-2R, CD + 4 and CD + 8 in patient with chronic pulmonary heart disease (CPHD).Methods The plasma slL-2R, CD + 4 and CD + 8 were measured by ELISA and APAAP in 30 cases during acute CPHD and miosis respectively.Results The plasma slL-2Rwas significant increase in acute duration of CPHD and decrease in mild duration of CPHD, but higher than that of control group. The plasma CD + 4 was not obvious change during acute and miosis duration, but there was a significant different in acute group and control group. The CD + 4 /CD + 8 ratio was <1 in patients with acute CPHD.Conclusion Function of immunity reaction was abnormal in CPHD patients so that tracheobronchitis was continuous and obstinate.