急性肺损伤患者血浆颗粒膜蛋白-140改变的临床意义

Clinical Significance of Plasma Granular Membrane Protein-140 Changes in Patients with Acute Lung Injury

目的 :观察急性肺损伤 (ALI)患者血浆颗粒膜蛋白 140 (GMP 140 )及相关指标的改变 ,并探讨其临床意义。方法 :对 32例ALI患者进行多时间点检测血浆中GMP 140、循环内皮细胞(CEC)、内皮素 1(ET 1)和血管紧张素转换酶 (ACE)含量 ,并设健康对照组。结果 :肺损伤后 1h内 ,血中GMP 140、CEC、ET 1和ACE均显著升高并持续 8h ,血浆GMP 140早期升高 ,幅度较大 ,1h内 5 0 .5 6± 8.79μg/L ,较对照组16 .32± 4.5 1μg/L高 (>3倍 ) ,伤后 2h达高峰 (5 4.38± 9.94μg/L) ,各时间点与对照组比较 ,P均 <0 .0 1;并与其他指标有较好的相关性。结论 :血浆GMP 140可作为ALI患者的病情监测和评估的有用指标。

Objective:To evaluate the significance of plasma level of granular membrane protein 140 (GMP 140) and the related parameters in patients with acute lung injury (ALI).Methods:32 patients with ALI were evaluated.GMP 140,circulating endothelial cells (CEC),endothelin 1 (ET 1) and angiotension converting enzyme (ACE) were determined at various time intervals.Results:Plasma GMP 140,ET 1,ACE and CEC level began to rise 1h after ALI and persisted in high level during 8h observation period.Plasma GMP 140 increased markedly at early stage of injury with 3 fold higher than control group ( P < 0.01 ).It achieved its peak at the 2nd hour and well correlated with the other parameters.Conclusions:GMP 140 might be a useful parameter for monitoring and evaluating the disease status in patients with ALI.