摘要
目的 :观察胆必清颗粒对实验性急性胆管炎的防治作用。方法 :建立家兔急性细菌性胆管炎模型 ,用直接镜检法计数血小板 (PL)、白细胞 (WBC) ,磷酸苯二钠法测定血清碱性磷酸酶 (AKP)总活力 ,对其手术前后的变化进行比较 ,病理检查肝组织形态学改变。结果 :胆管炎模型组手术后与手术前比较 ,血PL计数显著降低 ,WBC计数和AKP活力明显升高 ,其差值变化与手术对照组比较有显著性差异 (P<0.01) ,病理检查显示肝组织和肝内胆管存在明显炎性改变 ;各胆必清组均能不同程度地抑制上述指标的变化 (P<0.05) ,改善形态学损害。结论
Objective: To observe the preventive and therapeutic effects of Danbiqing Granule on acute bacterial cholangitis. Methods: Acute bacterial cholangitis model of rabbit was established.Blood PL,WBC counts were measured directly under the microscope.Serum AKP activity was measured by a method of disodium phenyl orthophosphate. And their changes between postoperation and preoperation were compared. The morphologic changes of liver tissue was also observed.Results: After operation ,blood PL decreased and WBC and AKP activity was increased markedly in cholangitis group compared with preoperation,and their changes had statistical significance compared with control group(P<0.01).Significant inflammatory changes were also observed in liver tissue and biliferous ducts.Danbiqing inhibited these changes in a different degree(P<0.05),and alleviated the morphologic injury. Conclusion: Danbiqing granule has good preventive and therapeutic effects on acute bacterial cholangitis in rabbits.
出处
《天津医科大学学报》
2001年第4期468-468,477,共2页
Journal of Tianjin Medical University
基金
天津市自然科学基金95重点攻关项目资助 (编号 :983113411)
