糖皮质激素吸入疗法对哮喘儿童生长的影响

The effect of inhaled glucocorticosteroid therapy on growth of asthmatic children

目的 :探讨布地奈得 (BUD)吸入1a对哮喘儿童生长的影响。方法 :持续1a吸入BUD气雾剂 (剂量为200～800μg/d)的哮喘患儿60例 (轻中度组36例 ,重度组24例 )及正常对照组30例 ,分别检测24h尿17 -羟皮质醇 (17 -OHCS)、17 -酮类固醇 (17-KS) ;吸入BUD两组、对照组及未用BUD组 (17例哮喘患儿 ) ,在研究的1a前后分别测量身高 ,并计算身高增长速率 (GV)。结果 :吸入BUD两组 ,经1a治疗 ,尿17-OHCS、17 -KS无明显变化 ,但低于对照组 ;BUD两组、未用BUD组身高和GV值无明显变化 ,但低于对照组。结论 :<800μg/dBUD持续吸入1a对哮喘儿童生长无明显影响 ,哮喘影响儿童生长。

Objective: To evaluate the effect of inhaled budesonide(BUD) in one year on growth of asthmatic children. Methods: Twenty four hours urine 17-hydroxycorticosteroid (17-OHCS) and 17-ketosteroid (17-KS) were detected in asthmatic children 60 cases(36 cases of mild and moderate degree group, 24 cases of severe degree group) of inhaled aerosol BUD in one year and normal control group. Before and after the study, measured body height and calculated one year growth velocity(GV) in 2 groups of inhaled BUD, control group and uninhaled BUD group (17 cases of asthmatic children).Results: After one year treatment, urine 17-OHCS and 17-KS did not significant change in 2 groups of inhaled BUD, but they were lower than those of control group. Body height and GV value did not significant change in 2 groups of inhaled BUD and uninhaled BUD group, but they were lower than those of control group. Conclusion: The effect of persistent inhaled BUD (<800μg/d) in one year on growth of asthmatic children was not significant. Asthma may induce growth delay in asthmatic children.