口腔鳞状细胞癌DNA含量的测定及意义

The significance of DNA content in oral squamous cell carcinoma

目的 :探讨细胞核 DNA含量在判别口腔鳞状细胞癌 ( SCC)生物学行为中的意义。方法 :应用图象细胞计 ( ICM)分析 18例口腔鳞状细胞癌的 DNA含量和细胞周期。结果 :SCC中 DNA指数 ( DI)和增殖指数 ( PI)显著高于正常上皮 ( P<0 .0 5 ) ,随着 SCC病理学分级的升高 DI值和 PI值明显升高 ( P<0 .0 5 )。结论 :用 ICM检测细胞 DNA含量 ,分析细胞周期 ,有助于了解鳞状细胞癌的增殖能力和恶性程度 ,对指导预后和评价治疗具有重要意义。

Objective: To study the significance of DNA content in oral squamous cell carcinoma (SCC).Methods: DNA content and cell cycle of the cells in 18 cases of oral SCC were analized by image cytometry (ICM). Results: The DNA index (DI) and proliferation index (PI) were remarkably heigher in SCC than in normal epithelium ( P <0.05). The DI and PI raised with the increase of SCC degree ( P <0.05).Conclusion: DI and PI are correlated with the oncogenesis and development of oral SCC.