羟基磷灰石人工骨体外降解实验

Degradation of HA artificial bone in vitro

目的 :探讨在体外条件下羟基磷灰石人工骨 ( HAB)材料的降解规律。方法 :将材料放入磷酸盐缓冲液和蒸馏水中 ,观察在不同时间点其表面形态、重量、p H值、机械强度的变化。结果 :羟基磷灰石人工骨材料在磷酸盐缓冲液中 4周时开始降解 ,8周前重量丧失速度较快 ,8周后速度减缓 ;4～ 12周压缩强度降低幅度较大 ;p H值先降后升 ,2 8周时接近中性。结论 :羟基磷灰石人工骨材料具有一定的可降解性 ,材料降解引起材料压缩强度和 p H值的显著变化。

砄bjective: To study the rule of the degradation of HA artificial bone(HAB). Methods: The samples of HAB were immersed in PBS or distilled water (DW),the changes of the shape, weight, compressive strength of the samples and pH value of the immersion solutions were measred at the intervals of 2 or 4 weeks until 28 weeks. Results: At 4 weeks, HAB began to be degraded, 8 weeks later, the speed of the degradation slowed down. From 4 to 12 weeks, the compressive strength decreased rapidly. The pH value of the immersion solutions decreased from 2 to 12 weeks,but increased from 12 to 28 weeks when it was close to the neutral value. Conclusion: HA artificial bone can be degraded in PBS solution, and the degradation can cause noticeable changes of the compressive strength of the material and pH value of the immersion solution.