大蒜素对不同中医证型不稳定性心绞痛及其血液流变的影响

Effects of Garlicin on Different TCM Types of Unstable Angina Pectoris and Their Blood Rheology

观察大蒜素对不同中医证型不稳定性心绞痛疗效的差异。选择不稳定性心绞痛患者 55例随机分为大蒜素组 34例 ,硝酸甘油组 2 1例 ,治疗 10日后 ,观察疗程前后症状、心电图、血液流变学指标变化。结果示症状有效率和心电图有效率在大蒜素组和硝酸甘油组组间比较无显著差异 ;对偏寒证不稳定心绞痛的有效率在大蒜素组为 10 0 % ,硝酸甘油组为 75% ;大蒜素对偏寒型不稳定心绞痛的有效率为 10 0 % ,而对偏热者症状有效率为 54% (P <0 0 0 1) ;大蒜素可明显改善寒证患者的血流变 (P <0 0 5) ,热证则呈相反变化。提示大蒜素对偏寒证不稳定心绞痛的疗效优于硝酸甘油 ;大蒜素对偏寒证不稳定心绞痛的疗效优于偏热证不稳定心绞痛 ,并可明显改善寒证患者的血流变。

The study was to observe the effects of garlicin on different TCM types of unstable angina pectoris (UAP). 55 Cases of UAP were randomly divided into the garlicin group (consisting of 34 patients) and the nitroglycerin group (consisting of 21 patients), and the changes in symptoms, ECG and blood rheology in patients of both groups were observed before the treatment and 10 days after the treatment. The results showed that there was no significant difference between the effective rates of symptomatic and ECG improvements in both groups; the effective rate of the cold type of UAP of the garlicin group was 100% while that of the nitroglycerin group was 75%. The results also showed that the effective rate of garlicin in treating the febrile type of UAP was 54% ( P <0.001); garlicin had markedly effects of improving the state of blood rheology in cases of the cold type of UAP ( P <0.05) while it had adverse effects on the state of blood rheology in cases of the febrile type of the disease. From the results it could be seen that the effects of garlicin on the cold type of UAP was better than that of nitroglycerin on the same type of UAP; garlicin had better effects on the cold type of UAP than on the febrile type of the disease, and could also markedly improve the state of blood rheology in patients with the cold type of UAP.