锰、锆、锂单独作用对大鼠肝脏脂质过氧化的影响

Effects of manganese, zircon and lithium alone on rat liver lipid peroxidation

采用丙二醛比色法 (体外法 )测定大鼠肝脏匀浆脂质过氧化物 (LPO) ,研究锰、锆、锂对大鼠肝脏脂质过氧化作用的影响。结果表明 ,锰、锆浓度分别在 (9 86 2～ 1.972 )× 10 - 4 nmol L和 (0 1972～ 9 86 2 )× 10 - 5nmol L时对肝脏LPO起抑制作用 (P <0 0 1) ;锂浓度在 (19 72～ 1 972 )× 10 - 4 nmol L时对大鼠肝脏脂质过氧化作用在高浓度起诱导作用 ,在低浓度起抑制作用。提示痕量锰、超痕量锆和锂可以抑制大鼠肝脏的脂质过氧化代谢 ,痕量锂对大鼠肝脏的脂质过氧化具有诱导作用。

Lipid peroxide (LPO) in rat liver was detected by malondiadehyde (MDA) colorimetry. The effect of manganese, zircon and lithium alone on lipid peroxidation in rat liver was also studied. The results showed that manganese and zircon at the doses of (9 862～1 972)×10 -4 and (0 1972～9 862)×10 -5 nmol/L respectively decreased LPO in rat liver( P <0 01). Lithium inhibited lipid peroxidation at the dose of (19 72～1 972)×10 -4 nmol/L, and induced lipid peroxidation at higher concentration.