急性缺氧条件下脑认知功能发生障碍的时段

Locating the Impairment of Human Cognitive Function during Hypoxia.

目的确定急性缺氧条件下脑认知功能障碍的发生阶段。方法 1 4名被试者在 50 0 0m模拟高度(吸低氧混合气体 )分别进行 2种不同声强值 (55dB、80dB)的听觉Oddball测试 ,记录脑电图 (EEG)、反应时 (RT) ,EEG经平均叠加处理提取出脑事件相关电位 (ERP)中的P3潜时。以P3潜时和RT为主要指标采用加因素法 (AFM)评定脑认知功能障碍发生的具体时段。结果P3潜时与RT在声强及缺氧高度间出现交互作用。

Objective To find the location where the human brain cognitive function impairs under hypoxia. Method 14 healthy males ,aged 18～20 years,performed auditory Oddball test of two different intensities(55 dB、80 dB)during exposure to 5000 m by breathing low oxygen mixture.EEG and Reaction Time(RT) were recorded. P 3 ,the component of ERP, was extracted from EEG. P 3 latency and RT were used as indices of the experiment.Additive Factors Method was used to analyse the result of the experiment. Result Interaction between hypoxia and stimulus intensity was found for P 3 latency and RT. Conclusion Acute hypoxia influnces the preprocessing stage of information processing.