大网膜内脾片自体移植形态及功能研究

Experimental Study on the Morphology and Function of Splenic Autotransplantation in Omental Pouch

本实验是观察大白鼠大网膜内脾片自体移值后移植脾组织的再生、形态结构及功能的研究,结果表明自体移植脾组织片可以存活再生,重建脾脏的组织结构及一定程度地恢复了脾脏摄取变性红细胞,滤过血Howell-Jolly小体和空泡红细胞以及抗御肺炎球菌侵袭等功能。

This study was performed in young Wistar rats. One hundred Wistar rats were divided into three groups. Group 1:30 rats, served as sham controls and had only celiotomy. Group 2:30 rats, underwent totol splenctomy. Group3:40 rats, had splenic autotransplantation after splenectomy. Observations on the regeneration as well as morphology and function of the splenic autotranplants indicated: 1. the weight of the splenic implants increased significantly in 12 weeks postoperatively; 2. the splenic implants had reconstructed the histologic structure of the spleen 3: the splenic autotransplants could sequstrate 99mTc labeled red blood cells, filter Howell-Jolly bodies and pocked erythrocytes in the blood remove pneumococcal bacteria and decrease the morbidity of OPSI.