摘要
107例各类肾脏病患者,按疾病类型分成慢性肾炎、肾病、肾小管疾病及慢性肾功能不全4组,用放射免疫法分别测定尿Alb、β_2-MG、IgG、IgA、SIgA值。除肾小管疾病组外,各组尿蛋白系列值均较正常组有非常显著增高(P<0.01);慢性肾盂肾炎急性发作者尿β_2-MC有显著增高;各组间尿Alb/β_2-MG值有显著性差异;肾病组尿Alb/IgG值与同步尿蛋白盘状电泳呈正相关。提示尿蛋白系列测定对了解肾脏受损的部位和程度及了解肾小球基底膜选择性程度有很大帮助,在某种程度上可替代尿蛋白盘状电泳。
107 patients with renal disease of different types were divided into four groups (nephrotic syndrome, chronic glomerulonephritis, renal tubular lesion and chronic renal failure). Urinary proteins (urine albumin, β_2-MG, IgG, IgA and secretory IgA) contents were determined by radiommunoassay method. It was found that in all but one with renal tubular lesion showing significantly increased than that of the normal (P<0.01). In active stage of chronic pyelonephritis there was significantly increased β_2-MG level. There was a significantly difference of the urine albumin/urine β_2-MG in each group (P<0.05～0.001). There was a positive correlation between urine albumin/urine IgG and urine SDS-disc electrophoresis in nephrotic syndrome. Thes study signifies that estimatiom of urinary proteins may be helpful to understanding either the affected position and degree in the kidney or the selective degree on glomerular basement membrane. It may replace urine SDS-disc electrophoresis in some degrees.
出处
《上海第二医科大学学报》
CSCD
1991年第1期32-35,共4页
Acta Universitatis Medicinalis Secondae Shanghai
