成人急性非淋巴细胞白血病83例疗效分析

Analysis of Therapeutic Effects in 83 Adult Patients with Acute Nonlymphocytic Leukemia

本文分析83例初治急性非淋巴细胞白血病(acute non-lymphocytic leukemia,ANLL)的疗效,完全缓解42例(50.6%),部分缓解2例(2.4%),总有效率53%,观察五种诱导方案的完全缓解率,发现随化疗强度增加完全缓解率有逐渐递增的趋势,且1～2个疗程达完全缓解者较之2疗程以上达完全缓解的中位缓解期有明显差异(P<0.05),年龄、外周血白细胞数和原幼细胞数与预后有关。

Therapeutic effects of 83 adult patients with ANLL were analyzed. 42 cases achieved CR (50.6%), and that total response rate was 53 percent. With respect to the clinical outcome of five protocols often used for the treatment of leukemia, we found that the CR rate would rise with more intensive chemotherapy. There was a significant difference (P<0.05) in the median remission duration between patients treated with 1-2 coures and those receiving more than 2 coures of the above regimens. Age WBC, and the percentage of blasts plus promyelocytes also are relevant to the therapeutic results.