冠心病患者血清元素变化与临床诊断意义

Serum Trace Element Level and Its Diagnostic Value in Coronary Heart Disease

文章报告53例经冠状动脉造影的冠心病人和47例非冠心病人的7种血清元素测定结果,冠心组血清镁(Mg)、钙(Ca)、硒(Se)及锌(Zn)均明显低于对照组(p<0.0001),铜(Cu)高于对照组(p<0.0001),锰(Mn)及锶(Sr)于两组间无明显统计学差别(分别为P>0.5及P>0.05)。应用多因子判别分析法对冠心病的识别率为83%,剔除心肌梗塞患者后识别率达85.4%。判别方程的敏感性为83.02%,特异性为91.15%,可作为冠心病的辅助诊断方法。

Serum levels of seven trace elements were determined in 53 patients with coronary heart disease confirmed by coronary angiography and 47 normal subjects. It was found that serum levels of magnesium, calcium, selenium and zinc were significantly higher in patients with coronary heart disease than that of normal subjects (P<0.0001). No statistically significant difference was found in serum strontium and mangnese levels between patients with coronary heart disease and normal subjects.Multivariate discriminant analysis showed that there was a close correlation between serum levels of calcium, magnesium, copper, selenium and strotium and the presence of coronary heart disease. The predictive value of discriminant regression equation using these five variables was 82.69%, with a sensitivity of 83.0% and specificity of 91.5%. It can be used as an adjunvant in the diagnosis of coronary heart disease.