抗角蛋白自身抗体对银屑病裸鼠皮损移植模型的影响

Effect of anti-keratin autoantibody on psoriatic skin grafts on nude mice

目的 建立银屑病裸鼠皮损移植模型 ,观察抗角蛋白自身抗体 (AK auto Ab)对银屑病动物模型的影响 .方法 将人体银屑病皮损组织块移植于裸鼠背部 ,移植后一组裸鼠腹腔注射纯化的人体 AK auto Ab,另一组裸鼠腹腔注射生理盐水作为对照 ,从组织病理变化评价银屑病裸鼠皮损移植模型的可行性以及 AK auto Ab对移植的银屑病皮片组织学改变的影响 .结果 对照组皮损植片相当一段时间内能稳定地维持银屑病的部分重要组织学改变 ,而 AK auto Ab注射组则可使银屑病的组织学特征的维持时间明显缩短 .结论 银屑病裸鼠皮损移植模型是银屑病短期内理想的动物模型 ,AKauto

AIM To investigate the effect of anti keratin autoantibidy (AK auto Ab) on psoriatic skin grafts on nude mice. METHODS The animal model for psoriasis was established by transplanting psoriatic lesional skin to nude mice. Effects of AK auto Ab on the psoriatic skin grafts wereobserved by means of histological score. RESULTS The psoriatic skin grafts on nude mice maintained most important histologic features of psoriasis several weeks after grafting. The injection of AK auto Ab could promote reduction of some of the histologic features. CONCLUSION It is suggested that the nude mouse is a suitable model for the study of psoriasis,AK auto Ab can improve the recovery of psoriasiform dermatitis.