电针对脑缺血大鼠的脑保护作用

The Protective Effect of Electroacupuncture on the Ischemic Brain

目的 研究 Wistar大鼠局灶脑缺血后电针对神经缺损评分、脑梗塞体积、组织病理学指标的影响。 方法 线栓法闭塞大鼠大脑中动脉 ,制备局灶脑缺血 /再灌注模型。用神经病学评分、神经病理等方法检测电针“合谷”穴区对局灶脑缺血 3 h及再灌注 3 h、6 h时神经缺损评分、脑梗塞体积、组织病理学指标的影响。 结果 电针可缩小局灶脑梗塞体积 ,改善神经缺损评分 ,改善组织病理学指标。 结论 电针可对局灶脑缺血 /再灌注

Purpose To investigate the influence of electroacupuncture on neural deficit score, cerebral infarct volume and histopathologic indices after focla cerebral ischemia in Wistar rats. Methods A rat model of focal cerebral ischemia/reperfusion was made by filament occlusion of the middle cerebral artery. Neuropathic scoring and a neuopathologic method were used to evaluate the influence of electroacupuncture of point Hegu(LI 4) on neural deficit score, cerebral infarct volume and histopathologic indices 3 hrs after focal cerebral ischemia and 3 hrs and 6 hrs after reperfusion. Results Electroacupuncture could reduce the volume of focal cerebral infarct and improve neural deficit score and histopathologic indices. Conclusion Electroacupuncture can produce a marked protecting effect on the brain in Wistar rats with focal cerebral ischemia/reperfusion.