乌龙茶减肥作用机制的研究

THE ANTI-OBESITY ACTION OF OOLONG TEA

目的 : 乌龙茶是否能抑制由于喂饲高脂饲料而引起的肥胖。方法 : 以添加乌龙茶的高脂肪食喂饲小鼠 1 0 w,检查小鼠体重、肝脏重量、脂肪组织重量以及肝中甘油三酯的含量 ;从乌龙茶中分离促进脂肪分解的活性物质并检查在脂肪细胞中对去甲肾上腺素诱导脂肪分解的作用。结果 : 乌龙茶可以抑制喂饲高脂饲料引起的肥胖和脂肪肝。乌龙茶的水提取物能够促进去甲肾上腺素诱导的脂肪分解 ,其活性成分之一经鉴定是咖啡因。咖啡因能增强去甲肾上腺素诱导脂肪细胞中的脂肪分解作用。乌龙茶能抑制胰脂肪酶的活性。结论 : 乌龙茶的减肥作用可能是由于乌龙茶中所含具有促进脂肪分解作用的咖啡因和乌龙茶中其他有抑制脂肪吸收的物质所致。

Objective: The present study was performed to clarify whether oolong tea prevented obesity induced in mice by oral administration of a high fat diet. Methods: High fat diet-induced obese mice were treated with oolong tea for 10 weeks. The effects of various active fractions isolated from oolong tea on norepinephrine-induced lipolysis were examined in isolated fat cells. Results: Oolong tea prevented obesity and fatty liver induced by a high fat diet. The active substance in the water extract of oolong tea was identified as caffeine, which enhanced norepinephrine-induced lipolysis in fat cells. Oolong tea extract inhibited pancreatic lipase activity. Conclusion: It is demonstrated that the anti-obesity effects of oolong tea in high-fat diet-treated mice may be due partly to the enhancing effects of caffeine isolated from oolong tea on norepinephrine-induced lipolysis in adipose tissue, and partly to the inhibitory action of some other substances in oolong tea on pancreatic lipase activity.