人类乳头状瘤病毒与肺癌的病因关系研究(三)

The etiologic relationship of HPV infection to the development of lung cancer

目的继续研究人乳头瘤病毒与肺癌的病因关系。方法采用多重聚合酶链反应 (PCR)技术 ,对 7种肺组织进行HPV8、HPV18及HPV35型检测。结果在鳞癌及其邻近鳞状化生上皮中 ,HPV18和HPV35的检出率无明显差异 ,肺鳞癌和腺癌中 ,两者亦无明显差异 ,在肺鳞癌和正常支气管粘膜中HPV18的检出率却有显著差异 (P <0 0 1)。结论HPV18和HPV35型感染与肺鳞癌和腺癌的发生有关 。

Objective To study the etiologic relationship of HPV infection to the development of lung cancer. Methods Seven tissues of lung were searched for the presence of HPV subtypes 8?18 and 35 by PCR. Results The detected rates of HPV18 and HPV35 had no significant difference ( P >0.05) between squamous cell carcinoma (SQ) and the squamous epithelium metaplasia adjacent tumors, and between SQ and adnocarcionma (AC). But, the detected rates of HPV18 had a significant difference ( P <0.01) between SQ and normal bronchial mucosa. Conclusion HPV18 and HPV35 infection contribute to the development AC and SQ of lung . The HPV18 could have a more high risk.