脑膜瘤微坏死与纤溶酶原激活抑制因子及预后的关系

Association of Micronecrosis with Plasminogen Activator Inhibitor-1 and Its Prognosis in Meningiomas

目的:探讨脑膜瘤微坏死与纤溶酶原激活抑制因子-1(PAI-1)和预后的关系。方法:采用ABC免疫组化方法检测90例脑膜瘤组织中PAI-1表达,分析其与临床病理因素之间的关系。结果:脑膜瘤微坏死发生率与PAI-1表达及恶性程度呈正相关(pearson列联系数分别为0.48和0.61,P<0.01);微坏死组脑膜瘤PAI-1表达阳性率85.2%(23/27),术后3年复发率40.7%,分别显著高于无微坏死组的9.5%(6/63)(P<0.01)和6.3%(P<0.01);微坏死组脑膜瘤5年生存率66.7%明显低于无微坏死组的95.2%(P<0.01)。结论:PAI-1可能是脑膜瘤发生微坏死的重要因子,脑膜瘤微坏死对判定恶性程度和预后有重要参考价值。

Objective:To investigate the association of micronecrosis with plasminogen acti-vator inhibitor-1(PAI-1)and its prognosis in meningiomas.Methods:The expression of PAI-1was examined with ABC immunohistochemical method in90cases of meningioma.Correlation between PAI-1expression with clinicopathologic factors was studied.Results:Micronecrosis of meningioma was positively correlated with PAI-1expression;The Pearson contingenct coefficient was P=0.48,P<0.01and that of malignancy the Pearson contingenct coeffient was P=0.61,P<0.01respectively.The positive rate of PAI-1expression(85.2%,23/27)and the three-year recurrnece rate of meningioma with micronecrosis(40.7%)were significantly higher than those without mi-cronecrosis(9.5%,6/63,P<0.01and6.3%,P<0.01,respectively).Five-year survival rate of pa-tients with meningioma micronecrosis(66.7%)was significantly lower than those without mi-cronecrosis(95.2%,P<0.01).Conclusion:PAI-1may be an important factor involving in meningioma micronecrosis.Micronecrosis examination is of value in understanding the degree of malignancy and prognosis of the disease.