羟基喜树碱联合DLF方案治疗晚期大肠癌

Preliminary Study on HCPT Combined with Leucovorin,5-FU and Cisplatin in the Treatment of Advanced Colorectal Cancer

目的:观察羟基喜树碱(Hydroxycamptothein,HCPT)、顺铂(Cisplatin,DDP)、醛氢叶酸(Leucovorin,LV)、5-氟脲嘧啶(Fluorouracil,5-FU)组成的HDLF方案对晚期大肠癌的疗效及不良反应。方法:治疗组27例HDLF方案化疗,HCPT6～8mg/m2,第1～5天,静滴;DDP30mg/m2,第1～3天,静滴;LV20mg/m2,第1～5天,静滴;5-FU500mg/m2,第1～5天,静滴。对照组18例DLF方案化疗,DDP、LV及5-FU,用法同治疗组。以上方案每4周重复。结果:HDLF方案DLF方案有效率、疾病进展时间(timetoprogression)分别为29.6%、27.7%(P=0.546和29周,P=0.238和22周)。主要不良反应为消化系统、血液毒性,多为Ⅰ～Ⅱ度,患者耐受良好。结论:HDLF方案治疗晚期大肠癌,可能有助于提高有效率、延缓疾病进展,值得临床进一步观察研究。

Objective:To observe the therapeutic effects and toxicity of HDLF(HCPT/DDP/LV/5-FU)regimen in the treatment of advanced colorectal cancer.Methods:Twenty-eight patients with advanced colorectal cancer were treated with HDLF regimen(HCPT6～8mg /m 2 /d1～5,DDP30mg /m 2 /d1～3,LV20mg /m 2 and5-FU500mg /m 2 /d1～5)and30cases treated with DLF regimen.All repeated every4weeks.Results:The response rate was29.6%in HDLF regimen and22.9%in DLF regimen(P=0.546),and the time to progression(TTP)was29weeks in the HDLF group and22weeks in the DLF one(P=0.0238).The main toxicity was gastrointestinal reaction and myelosuppression.All the side effects were mild and tolerable.Conclusion:HDLF regimen may be promising for treating advanced colorectal cancer and it is worthy of fur-ther clinical trial.