紫外分光光度法测定尿中氧氟沙星的排泄量

Determination of Ofloxacin Excretion in Urine by UV - spectrophotometry Method

目的：对国产氧氟沙星片药代动力学进行研究。方法：采用紫外分光光度法测定氧氟沙星尿药浓度。结果：药代动力学参数分别为：Ｋ＝０.１２７８ｈ；Ｔ１２＝５．９６ｈ；Ｘｕ０－２４＝１６５．８４ｍｇ；排泄率（Ｑ）＝８２８４％。结论：本法简便、快捷，可作为药代动力学研究和临床监测的有效方法。

AIM: To study the pharmacokinetic characteristics of domestic ofloxacin tablet. METHODS: A method of deter- mination of drug concentration in urine by UV-spectrophotometry was established. RESULTS: K = 0. 1 278/h; T1, 2 = 5. 96h, Xu0-24 = 165. 84mg; (Q) = 82. 84%. CONCLUSION: This method is simple and rapid, it is suitable for pharmacokinetics study and clinical monitoring.