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FUDR保留灌肠对直肠癌细胞增殖能力的影响 被引量:2

Influence of FUDR Through Retention-enema on Cell Proliferation of Rectal Carcinoma
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摘要 目的:比较氟脲嘧啶脱氧核苷(FUDR)、5-氟尿密啶(5-FU)保留灌肠对直肠癌增殖细胞抗原(PCNA)表达的影响。方法:直肠癌患者 80例,随机分成 FUDR组(30例)、5—FU组(30例)、对照组(20例),术前每晚分别灌入 FUDR(500mg)、5-FU(500mg)、生理盐水各20ml,行保留灌肠,连续 7天。第 1天、第 8天钳取癌灶粘膜送检,行PCNA免疫组化染色。结果:FUDR组与 5—FU组治疗后其 PCNA阳性细胞数均明显减少,且 FUDR组治疗后其 PCNA阳性细胞数减少较 5—FU组更为明显,而生理盐水对照组 PCNA变化无意义。结论:FUDR H 5—FU保留灌肠均可抑制直肠癌细胞增殖,且同一浓度的 FUDR作用较 5-FU更显著,故FUDR保留灌肠应作为直肠癌术前常规治疗方案。 AIM: To study the influence on the expression of proliferation cell nuclear antigen(PCNA) in rectal carcinoma through retention -enema with FUDR and 5 -FU. METHODS: 80 cases of rectal carcinomas were randomized into three groups: the FUDR group(30 cases), the 5-FU group(30 cases) and normal control group(20 cases), treated with FUDR(500mg), 5-FU(500mg) and normal saline(20ml ) everynight through retention - enema separately for serven days- Mucosa of rectal car cinoma were sampled and PCNA protein were simultaneously detected by imrnunohistochemical method on the first and eighth day. RESULTS: The expression of PCNA was significantly decreased in both FUDR group and 5 - FU group after treatment(P < 0. 01). The decrease in FUDR group was more obvious than that in 5-FU group(P < 0. 05), and the change in normal control group was of no significance(P >0. 1). CONCLUSION:The cell proliferation of rectal carcinoma could be inhibited by FUDR and 5-FU through retention-enema. The effects of FUDR was more obvious than that of 5-FU in the same concentration. so the treating method through retention-enema with FUDR should be used as a routine therapeutic scheme befOre operation.
出处 《中国药房》 CAS CSCD 2001年第9期546-547,共2页 China Pharmacy
关键词 氟脲嘧啶脱氧核苷 直肠癌 局部化疗 治疗性灌肠 FUDR rectal carcinorna local chemotherapy therapeutic enema
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  • 1俞立民.大肠癌的局部化疗[J].中国肛肠病杂志,2000,20(6):34-37. 被引量:3
  • 2Earlam S, Glover C, Davies M, et al. Effect of regional and systemic fluorinated pyrimidine chemotherapy on quality of life in colorectal liver metastasis patients[J].J Clin Oncol, 1997 , 15:2 022.
  • 3Fontanini G, Pingitore R, Bigini D,et al. Growth fraction in non- small cell lung cancer estimated by prol iferating cell nuclear antigen and comparison with Ki67 labeling and DNA flow cytometry data[J]. Am J Pathol , 1992,141:1 285.

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