4厂家产马来酸氯苯那敏片溶出度比较

Comparison of the Dissolubility of Chlorphenamine Maleate Tablets Produced by 4 Different Factories

目的：比较市场上不同厂家马来酸氯苯那敏片溶出度。方法：采用桨法对国内４个厂家的马来酸氯苯那敏片进行体外溶出度测定，进行Ｔ５０、Ｔｄ、ｍ参娄方差分析。结果：４个厂家抽检品溶出参数分别为：Ｔ５０：３０．３１９７、１７．６９５、２０．１０３８、１４．３６５１；Ｔｄ：３４．６０８８、２６．７ １６２、２８．０ ５１４、２２．１５９３；ｍ：２．７ ６７６、０．８ ５０２、１．０９９２、０．８ ４４８。结论：经统计学处理，不同厂家马来酸氯苯那敏片抽检品溶出参数有显著性差异（Ｐ＜０．０１）。

OBJECTIVE:To compare the in vitro dissolubility of four kinds of commercial chlorphenamine maleate tablets. METHODS: To determine the dissolubility of four kinds of domestic commercial chlorphenamine meleate tablets by paddle method and to analyse the dissolution parameters, T50, Td, m, by variance analysis method. RESULTS: The dissolution parame- ters of the different tablets were T50(30. 3 197, 17. 3 695, 20. 1038, l4. 3 651), Td(34. 6 088, 26. 7 162, 28. 0 514, 22. 1 593)and m (2. 7 676, 0. 8 505, 1. 0 992, 0. 8 448). CONCLUSION: The statistical results indicated that there were significant differences between them(P < 0. 01 ).