高压氧综合治疗突发性耳聋疗效观察

Observation on the Effect of Treatment of Sudden Hearing Loss with Hyperbaric Oxygen

探讨高压氧结合药物治疗突发性耳聋的疗效及影响因素。方法:84例采用高压氧与药物综合治疗(HBO组),40例对照组采用单纯药物治疗。高压氧治疗采用压力2.2～2.5ATA,吸氧30min×2+10min,每日1～2次;药物治疗采用低分子右旋糖酐,复方丹参注射液,ATP、COA、维生素B_1、维生素B_(12)等治疗。结果:HBO组总有效率91.0％,对照组为63.8％,两组疗效有非常显著性差异(P<0.01),病程<2周及听力损伤≤55db者疗效明显优于病程>2周者及听阈>55db者。结论:高压氧综合治疗突发性耳聋的疗效明显优于单纯药物治疗。病程和听力损失程度是影响疗效的两个重要因素,早期治疗能够提高治愈率和有效率。

To approach the therapeutic effect and influential factors of hyperbaric oxygen(HBO) and drugs for treating sudden hearing loss.Methods:Hyperbaric oxygen and drug treatment was used in 84 cases(HBO group) .The routine drugs treatment was used in 40 cases(control group) In the HBO therapy the pressure was kept at 2.2 to 2.5 ATA,30min × 2(10min air break) in one treatment,and it was given once or twice daily. Drugs were dextran 40 glucose injection,compound salvia miltiorrhiza injection, ATP, COA and vitamini B1,vitamini B12 ect. Results:The total effective rate in HBO group was 91.0% ,but that in control group was 63.8%. There was remakable difference( P < 0.01) -The therapeutic effects of patients of which the disease period was less than two weeks and hearing loss were lower than 55db were significantly higher than those whose period was longer than two weeks and hearing loss was higher than 55db. Conclusion:The therapeutic effects of HBO are higher than routine drugs treatment.The disease periods and hearing loss are two important factors for therapeutic effects. The early treatment time can raise the cure rate and effective rate.