氯氮平合并丙戊酸钠治疗难治性精神分裂症的疗效分析

Therapeutic effect of clozapine with sodium valproate in treatment-refractor schizophrenia.

目的 探讨氯氮平合并丙戊酸钠治疗难治性精神分裂症的疗效。方法 抽取 6 4例难治性精神分裂症患者给予氯氮平≥ 40 0mg/日 ,合并丙戊酸钠≥ 80 0mg/日 ,治疗 3个月 ,用简明精神病量表 (BPRS)及药物副反应量表 (TESS)评定疗效及副作用 ,并对其它相关因素进行分析。结果 发现氯氮平合并丙戊酸钠治疗难治性精神分裂症阳性、阴性症状均有效 ,总有效率为 5 6 .2 %,尤其对女性及 <2 2岁的患者疗效好 ,对激活因子及敌对猜疑因子疗效亦佳 ,副作用轻微。结论 氯氮平合并丙戊酸钠是治疗难治性精神分裂症 (尤其是对女性及 <2 2岁患者 )

Objective To study the therapeutic effect of clozapine with sodium valproate in treatment-refractory schizophrenia .Methods 64 cases of treatment-refractory schizophrenia were treated by clozapine≥400mg/d,valproate≥800mg/d.We cheekgd the therapeutic effect and side-effect and analyzed other related factors by BPRS and TESS over 3 months treatment.Results Clozapine with sodium valproate achieves effectively on both positive and negative symptoms of treatment-refractory schizophrenia.Total effect is 56.25%.Especial effectiveness shows in female and patients under 22.To active factors and anti-factors,it has good effect and minor side-effect.Conclusions Clozapine with sodium valproate performs effectively on treatment-refractory schizophrenia,especially to female and patients under 22.