补肾益心片对肾性高血压大鼠血浆过氧化脂质及性激素的影响

Effects of Bushen Yixin Tablet on Plasma Lipid Peroxide and Sexual Hormone in Renal Hypertension Rats

[目的 ]观察补肾益心片对肾血管性高血压大鼠血浆过氧化脂质及性激素的影响。 [方法 ]建立Goldblatt’s二肾一夹高血压模型 ,设补肾益心片高、中、低剂量组、开搏通组、生理盐水组、假手术组。治疗后检测相关指标。 [结果 ]补肾益心片可降低肾性高血压大鼠的血压 ,其高、中剂量组与治疗前及模型组比较差异均有非常常显著性意义 (P <0 .0 1 ) ,低剂量组与治疗前比较P <0 .0 5 ,与模型组比较P <0 .0 1 ;补肾益心片可降低肾性高血压大鼠血浆LPO水平 (与模型组比较P <0 .0 1 ) ,升高SOD、GSH -PX (与模型组比较P <0 .0 1 ) ;可降低高血压大鼠睾酮水平 (与模型组比较P <0 .0 1 )和升高雌二醇水平 (与模型组比较P <0 .0 1 )。[结论 ]补肾益心片具有确切的降压作用 ,并可使肾性高血压大鼠血浆LPO下降 ,SOD、GSH -PX回升 ,可纠正高血压大鼠睾酮和雌二醇的失调 ,开搏通无此作用。

To investigate the effects of Bushen Yixin Tablet (BYT) on plasma lipid peroxide (LPO) and sexual hormone in renal hypertension rats. Goldblatt's renal hypertension rat models were established. All rats were allocated to six groups: BYT groups (with high, moderate and low dosage of BYT respectively), captopril group, normal saline (NS) group and mimic-operation group. The treatment course lasted 4 weeks. Blood pressure was lowered in BYT groups (P< 0.05 or 0.01 as compared with that before treatment and the model group). Compared with the model group, BYT decreased plasma LPO level and increased SOD and GSH-Px levels and could also decrease the testosterone level and increase the estradiol level (P< 0.01 ).[Conclusion] BYT can markedly lower the blood pressure of renal vascular hypertension rats, decrease the plasma LPO level and increase SOD and GSH-Px levels, and correct the disorder between testosterone and estradiol, which can not be shown in captopril.