摘要
DNA拓扑异构酶 (topoisomerase ,Topo)是核基质成分之一 ,是一种调整DNA拓扑结构的核酶 ,在DNA的复制和转录过程中发挥着重要作用 ,故而成为许多抗肿瘤化疗药物的靶。针对TopoII的抗肿瘤化疗药物同样面临着耐药问题。
DNA topoisomerase,one kind of nuclear matrix is a kind of one of nuclear enzyme that can modify DNA topology.For it plays a important role in DNA replication and transcription,it becomes the target of some anticancer drugs.The same as other anticancer drugs,DNA topoisomerase has to face the problem of drug resistance.This article is mainly to illustrate the relationship between DNA topoisomerase II and the mechanism of tumor drug resistance.
出处
《肿瘤防治杂志》
2001年第6期675-677,共3页
China Journal of Cancer Prevention and Treatment
基金
广东省自然科学基金资助项目 ( 990 799)
广东省自然科学基金博士启动基金资助项目 ( 9840 6 8)
广东省医学科学技术研究基金资助项目 (B199910 5 )
关键词
DNA拓扑异构酶
药物耐受性
抗药性
肿瘤
DNA topoisomerase II
drug tolerance
Drug resistance,neoplasm
review literature
