摘要
目的 :比较不同厂家的盐酸氨溴索片溶出度。方法 :按国家药品监督管理局试行标准WS-430(X -370)-2000 ,测定4厂家的盐酸氨溴索片溶出度。结果 :各厂家的盐酸氨溴索片在45min时累积溶出量均>80 % ,符合规定。经方差分析 ,威布尔分布函数参数m、T50 和Td 都有极显著性差异 (P<0.01)。结论
OBJECTIVE:To compare the dissolubility of ambroxol hydrochloride tablets from four different manufacturers METHODS:To determine the dissolubility of ambroxol hydrochloride tablets according to Chinese WS-430(X-370)-2000 RESULTS:The accumulative dissolving quantity of all preparations exceeded 80% in 45 minutes The comparison of Weibull parameters,m,T50 and Td,showed significant differences(P<0 01) CONCLUSION:The dissolubilities of ambroxol hydrochloride tablets from four different manufacturers have significant differences
出处
《中国药房》
CAS
CSCD
2001年第12期748-749,共2页
China Pharmacy
关键词
盐酸氨溴索
片剂
溶出度
比较
ambroxol hydrochloride
tablet
dissolubility
comparison
