P53与肺癌病理、CT征象及预后的关系

Study on the Relationship between P53 Gene and Pathology,CT Imaging and Prognosis of Lung Cancer

目的 探讨 P5 3基因突变与肺癌的临床病理、CT征象、TNM分期及预后的关系。方法 收集 146例肺癌患者的标本 ,分别行 HE染色观察基本病理情况和 SP法免疫组化染色检测 P5 3表达结果。结果 146例周围型肺癌中 ,有深分叶、细毛刺、棘状突起、肿瘤强化增 CT值 >2 0 Hu者 ,其 P5 3基因表达率明显高于无深分叶、细毛刺、棘状突起、肿瘤强化增 CT值 <2 0 Hu(P<0 .0 1)。肿瘤大小、空洞、空泡征、空气支气管征、胸膜凹陷征与 P5 3表达无关 (P>0 .0 5 )。P5 3蛋白免疫组化阳性 75例 (5 1.36 % ) ,5 a生存率分析 ,P5 3基因表达组明显低于无 P5 3异常表达组。结论 P5 3基因突变可作为判断周围型肺癌恶性程度及预后的重要指标之一。 CT表现有深分叶、细毛刺、棘状突起、肿瘤强化增 CT值 >2 0 Hu者可能与 P5 3基因异常表达有关 。

Objective To investigate the relationship between P53 gene mutations and pathology,CT imaging,and prognosis of lung cancer.Methods 146 cases of lung carcinoma were reviewed retrospectively.HE staining and immunohistochemical SP method were performed to observe the general pathological changes and the expression of P53 respectively.Results The expression of P53 in lung carcinoma with deep lobulation,thin specula,thorn spicule,Enhanced density >20Hu was significantly higher compared with the carcinoma without the above mentioned characteristics.(P<0.01).The size,cavity,vacuole sign, air bronchogram, pleural indentation sign of the tumor showed no relationship with the expression of P53 gene (P>0.05).There were 75 cases (51.36%)of P53 protein positive.5 year survival rate of patients with P53 gene mutation was significantly lower than that of patients with nomal P53 expression.Conclusion The mutation of P53 could be one of valuble tools for estimating the severity and prognosis of lung carcinoma.The characteristics of CT imaging mentioned above might be related to P53 mutation,and also suggested a bad prognosis.