输血传播病毒(TTV)与原发性肝癌关系的研究

Investigation on Relationship Between TTV and Primary Liver Carcinoma

目的 了解输血传播病毒 (TTV)与原发性肝癌的关系。方法 选择原发性肝癌 48例 (实验组 )、非肝癌恶性肿瘤46例 (对照 1组 )和正常体检人员 5 8例 (对照 2组 ) ,检查 3组中TTV -DNA感染情况 ,进行病例对照研究。TTV -DNA检查用套氏PCR方法。结果 实验组TTV -DNA阳性率2 9 17%(14/4 8) ,对照 1组和对照 2组阳性率分别为 13 0 4%(6 /4 6 )、13 79%(8/5 8)。实验组与对照 1组和 2组相比接近显著性差异水平 (χ2 =3 6 46 ,P =0 0 5 6 ;χ2 =3 774,P =0 0 5 2 )。结论 TTV在原发性肝癌患者中检出率高 ,与正常对照组和非肝癌恶性肿瘤对照组相比接近显著性差异 ,TTV可能是原发性肝癌的一个致病因子。

Objective To investigate the relationship between TTV and primary liver carcinoma.Methods TTV-DNA was detected by nested PCR among three groups of population including 48 cases of primary liver carcinoma(case group),46 cases of non liver malignant tumor(control group 1)and 58 cases of general population(control group 2).Results The positive rate of TTV DNA was 29.17%(14/48) in case group,13.04%(6/46) in control group 1 and 13.79%(8/58) in control group 2 respectively.The difference between case group and control group 1 to 2 was closely remarkable(χ 2=3.646,P=0.056;χ 2=3.774,P=0.052,respectively).Conclusion TTV was existed in patients with primary liver carcinoma.The difference between case group and control group or nonliver malignant tumor group was closely remarkable.TTV may be an etiology factor for primary liver carcinoma.