围产期干预铅对新生儿神经行为发育影响

Effects of Perinatal Lead Intervention on Development of Newborn's Nervous Behavior

目的 探讨围产期干预铅对新生儿神经行为发育的影响。方法 采用Ebselen对围产期铅暴露进行干预流行病学调查及原子吸收法测定脐血铅、双道束荧光光度计测定脐血硒和新生儿出生后第 2 6～ 2 8天采用双盲法进行神经行为发育(NBNA)评分。结果 干预组脐血铅为 0 34 μmol/L ,显著低于对照组 (0 5 μmol/L) ,血硒、血锌、GSH -Px均高于对照组 (P均<0 0 1) ,LPO含量低于对照 (P <0 0 1)。干预组婴儿NBNA>35达 6 5 8%,显著优于对照 (P <0 0 1)。结论 围产期干预铅对减轻新生儿铅毒 ,改善微量营养素水平 ,提高抗氧化能力和保护新生儿智力正常发育均有明显的促进作用。

Objective To explore the effect of perinatal lead intervention on the development of newborn's nervous behavior.Methods The intervention epidemiological investigation was proceeded with the perinatal lead exposure by using Ebselen,and the umbilical blood lead was detected by atomic absorption method and the umbilical blood selenium was detected by double ways fluorescent photometer and the development of nervous behavior(NBNA) on day 26-28 of newborn was evaluated by using double blind method.Results The navel blood lead of intervention group was 0.34μmol/L,which was lower than the control group remarkably(0.5μmol/L),the blood selenium,zinc and GSH-Px were all higher than the control(P av <0.01),the content of LPO was lower than the control(P<0.01).The percent of NBNA>35 in intervention group was 65.8%,which is obviously better than the control(P<0.01).Conclusion The perinatal lead intervention has obviously promotion on alleviating the lead toxin of newborn,improving the level of trace nutrients,enhancing the ability of anti-oxidation and protecting the normal development of newborn's intelligence.