乳腺癌术前辅助动脉灌注化疗的血管影像学和病理学研究

Study on the vascular imaging and the pathology of breast cancer after neoadjuvant intraarterial chemotherapy

目的 观察乳腺癌术前辅助动脉灌注化疗的血管影像学和病理学的变化。方法 96例乳腺癌患者在动脉灌注化疗前行DSA造影 ,其术后标本进行病理变化研究。结果 乳腺癌的供血动脉多起源于胸外侧动脉和肩胛下动脉。乳腺癌的血管异常表现为不规则血管团 ,血管染色和血管湖形成。动脉灌注化疗后可发现肿瘤细胞退行性变、坏死 ,间质水肿 ,炎性细胞浸润和纤维组织增多。

Objective To observe the vascular imaging the pathological changes in the patients with breast cancer after neoadjuvant intraarterial chemotherapy. Methods Before intraarterial infusion, DSA were performed on 96 patients with breast cancer. Pathological changes were studied after operation. Results The blood supply of breast cancer mainly arises from the lateral thoracic and subscapular arteries. Abnormalities in the vascular architecture of breast cancer include irregular bolus arrangement, contrast staining, pooling of contrast material. Degeneracy and necrosis can be seen in the tumor cells after intraarterial chemotherapy. The stromal edema, infiltration of inflammatory cells and fibroplasia may take place. Conclusions Intraarterial infusion of neoadjuvant chemotherapy is effective in the patients with breast cancer.