局部应用消痔灵抗小鼠S180实体瘤研究

Study on local injection of Xiaozhiling for S-180 tumour of mice

目的 为局部应用消痔灵注射液治疗恶性肿瘤提供依据。方法 培育出S 180实体瘤小鼠模型 ,取消痔灵注射液 10ml/kg给实验组小鼠瘤体注射 ,取瘤体标本切片光镜及电镜下观察其病理变化并与对照组比较。结果 消痔灵组光镜下见肿瘤组织大片坏死 ,血管内有血栓形成 ;透射电镜下见血管内皮细胞破坏 ,红细胞外溢 ,微血栓形成 ,对照组肿瘤组织内无此变化。结论 消痔灵具有较强的抗肿瘤作用 。

Objective In order to provide the reasons for local injecting Xiaozhiling to treat malignant tumors. Methods 10 mice were subcutaneosly injected with S 180 Tumor cell to create tumor models and then Xiaozhiling 10ml/kg were intratumorly injected for 3 times.Finally,observation and comparison were made for the pathologic changes under optic and electronic microscopies. Results The results showed that Xiaozhiling had strong antitumor effect on S 180 tumor(adquate rate was 37.3%).Pathalogical exemination revealed that the tumor tissue necrosed obviously,some wesslincataneous cells breaked up, red blood cells extravasation,micro blood clots formed.No changes occurred in the control group. Conclusions Xiaozhiling could be a new drug for clinical treatment of malignant tumor.