地红霉素的合成

Synthesis of dirithromycin

以红霉素A为原料 ,经红霉素腙路线合成红霉素胺 ,与 2 (2 甲氧基乙氧基 )乙缩醛一步缩合得到地红霉素 ,总收率为 38.2 %。本研究对红霉素腙的合成方法及缩合反应的反应条件进行了改进。

Dirithromycin was synthesized from 9(s) erythromycylamine and 2 (2 methoxyethoxy) acetaldehy diethyl acetal by condensation with a total yield of 38.2%.9(s) Erythromycylamine was prepared from 9(s) erythromycin hydrazone.The conditions of the erythromycin hydrazone and condensation were improved.