期刊文献+

苯并呋喃衍生物扩冠活性研究

Research of the Coronary Dilating Activity of Benzofuran Derivative
下载PDF
导出
摘要 目的 :对合成的苯并呋喃衍生物进行药理活性的研究。方法 :采用 L angendorff法 ,进行豚鼠体外灌流实验。结果 :包括 5个化合物有较好的扩冠活性 ,其中 4个化合物未见文献报道。结论 :氯原子的引入增强苯并呋喃类化合物的扩冠活性 ,硝基、氨基、苄基等基团的引入会影响化合物的活性。 Objective: To research the coronary dilating activity of benzofuran derivatives which have been synthesized. Method: The langendroff method was used to conduct perfusion experiment in guinea pig in vitro. Results: Five compounds have better coronary dilating activity, and four of them haven't been reported. Conclusion: Introducing of chlorine atom increases coronary dilating activity of benzofuran derivatives, but introducing of groups such as nitro, amino and benzyl decrease the compound activity.
出处 《天津药学》 2001年第5期28-30,共3页 Tianjin Pharmacy
关键词 灌流 扩冠活性 苯并呋喃类衍生物 perfusion, coronary dilating activity, benzofuran derivative
  • 相关文献

参考文献3

  • 1[1]Brasseur R,Ruysschaert J M,Chatelain P. Molecular structure ofbenzbroma rone as determined by semi-empirical conformational analysis. Eur J Med, 1986,21:167
  • 2[2]Deltour G,Binon F,Henaux F,et al. The benzofuran series I benzofurans having activity as coronary dilators. Arch Internern Pharmaco, 1961,131: 84
  • 3[3]Pisanti N, Volterra G. Preliminary pharmacological studies on some benzofuan derivatives with coronary-dilating activity. Farmaco Ed Sci,1971,26:312

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部