2[1]Kelly CG, Todryk S, Kendal HL, et al. T-cell, adhesion, and B-cell epitopes of the cell surface Streptococcus mutans protein antigen I/II. Infect Immun, 1995,63(9):3649~3658
3[2]Okahashi N, Sasakawa C, Yoshikawa M, et al. Molecular characterization of a surface protein antigen gene from serotype c Streptococcus mutans, implicated in dental caries. Mol Microbiol, 1989,3(5):673~678
4[3]Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning. 2nd ed, New York: Cold Spring Harbor Laboratory Press, 1989:42~46
5[4]Talwar GP, Diwan M, Razvi F, et al. The impact of new technologies on vaccines. Natl Med J India, 1999,12(1):274~280
6[5]Tokuda M, Okahashi N, Takahashi I, et al. Complete nucleotide sequence of the gene for a surface protein antigen of Streptococcus sobrinus. Infect Immun, 1991,59(9):3309~3312
7[6]Staffileno LK, Hendricks M, Lapolla R, et al. Cloning of the amino terminal nucleotides of the antigen I/II of Streptococcus sobrinus and the immune response to the corresponding synthetic peptides. Arch Oral Biol, 1990,35(suppl):47S~52S
8[7]Sato Y, Roman M, Tighe H, et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science, 1996;273(3):352~354
9[8]Klinman DM, Yi Ak, Krieg AM, et al. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. PNA Sci USA, 1996,93(7):2879~2883
10[9]Pisetsky DS. DNA and the immune system. Ann Intern Med, 1997,126(2):169~171
1Keyes PH. Dental caries in the molar teeth of rats. J Dent Res, 1958,37(6):1088
2Russell MW, Hajshengallis G, Childers NK, et al. Secretory immunity in defense against cariogenic mutans streptococci. Caries Res, 1999,33(1):4
3Taubman MA, Holmberg CJ, Smith DJ, et al. Diepitopic construct of functionally and epitopically complementary peptides enhances immunogenicity, reactivity with glucosyltransferase, and protection from dental caries.Infect Immun, 2001, 69(7): 4210
4Jespersgaard C, Hajishengallis G, Huang Y, et al. Protective immunity against Streptococcus mutans infection in mice after intranasal immunization with the glucan-binding region of S. mutans glucosyltransferase.Infect Immun, 1999, 7(12): 6543
5Taubman MA, Smith DJ, Holmberg CJ, et al. Coimmunization with complementary glucosyltransferase peptides results in enhanced immunogenicity and protection against dental caries. Infect Immun, 2000,68(5):2698
6Hajishengallis G, Michalek SM. Current status of a mucosal vaccine against dental caries. Oral Microbiol Immunol, 1999,14 (1):1
7Hajishengallis G, Russell MW, Michalek SM. Comparison of an adherence domain and a structural region of Streptococcus mutans antigen I/II in protective immunity against dental caries in rats after intranasal immunization.Infect Immun, 1998, 66(4): 1740
8Pisetsky DS. The immunologic properties of DNA. J Immunol, 1996, 156(2):421
9Pisetsky DS. DNA and the immune system. Ann Intern med, 1997,126(2):169