中老年头颈部恶性肿瘤患者血清sIL-2R的检测及其临床意义

Detection and significance of the sIL-2R in middle and old patients with head-neck malignant carcinoma

目的 探讨中老年头颈部恶性肿瘤患者血清可溶性白介素 - 2受体 (s IL- 2 R)检测的临床意义。方法 采用双抗体夹心 (EL ISA)法 ,检测 90例头颈部恶性肿瘤患者、30例头颈部良性肿瘤患者、40例正常人的 s IL- 2 R水平。结果 恶性肿瘤患者 s IL- 2 R水平较良性肿瘤病人及正常人水平明显升高 (P<0 .0 1 ) ,良性肿瘤患者与正常人之间无差异 (P>0 .0 5)。结论 s IL- 2 R的增高可作为监视机体免疫功能、帮助诊断分析。

? Objective To detect and evaluate the sIL 2R in middle and old patients with head neck malignant carcinoma. Methods Using ELISA method, we detected the sIL 2R in 90 patients with head neck malignant carcinoma, 30 patients with head neck benign tumor and 40 healthy volunteers respectively. Results The sIL 2R level was significantly higher in malignant group than that in benign tumor group and healthy group (P<0.01), but there was no difference between the benign tumor group and healthy group (P<0.05). Conclusion The increase of sIL 2R was related with pathological grade and clinical stage in the patients of head neck tumor , so sIL 2R can be used as helpful index in diagnosis and prognosis for the diseases.