摘要
非甾体类抗炎药物 (NSAIDs)在临床上广泛用于解热、镇痛、抗炎 ,近年来大量研究表明它们具有抗肿瘤作用 ,并得到了流行病学、动物实验、体外实验的证实。本文重点介绍NSAIDs诱导肿瘤细胞凋亡 ,抑制肿瘤侵袭 。
出处
《国外医学（临床生物化学与检验学分册）》
2001年第6期310-311,共2页
Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
参考文献10
-
1StevensonMA,ZhaoMJ,AseaA,etal.SalicylicacidandaspirininhibittheactivityofRSK 2kinaseandrepressRSK2dependenttranscriptionofcyclicAMPresponseelementbindingproteinandNFkappaBresponsivegene[].JImmunol.1999
-
2.
-
3DongZ,HuangC,BrownRE,etal.Inhibitionofactivatorprotein1activityandneoplastictransformationbyaspirin[].Journal of Biochemistry.1997
-
4HuangC,MaWY,HanenbergerD,etal.InhibitionofultravioletBinducedactivatorprotein1(AP1)activitybyaspirininAP1luciferasetransgenicmice[].Journal of Biochemistry.1997
-
5MuronoS,YoshizakiT,SatoH,etal.AspirininhibitstumorcellinvasivenessinducedbyEpsteinBarrviruslatentmembraneprotein1throughsuppressionofmatrixmetalloproteinase9expression[].Cancer Research.2000
-
6TsujiiM,KawanoS,DuBoisRN,etal.Cyclooxygenase2expressioninhumancoloncancercellsincreasesmetastaticpotential[].Proceedings of the National Academy of Sciences of the United States of America.1997
-
7ShengH,ShaoJ,KirklandSC,etal.Inhititionofhumancoloncancercellgrowthbyselectiveinhibitionofcyclooxygenase2[].The Journal of Clinical Investigation.1997
-
8YamamotoY,YinMJ,LinKM,etal.SulindacinhititsactivationoftheNFkappaBpathway[].Journal of Biochemistry.1999
-
9McDadeTP,PeruginiRA,VittimbergaFJJr,etal.SalicylatesinhibitNFkappaBactivationandenhanceTNFalphainducedapoptosisinhumanpancreaticcancercells[].JSurgRes.1999
-
10ZimmermannKC,SarbiaM,WeberAA,etal.Cyclooxygenase2expressioninhumanesophagealcarcinoma[].Cancer Research.1999
同被引文献24
-
1沈铿 楼伟珍 见:沈铿 郎景和.环氧合酶(COX)与妇科肿瘤[A].见:沈铿，郎景和.妇科肿瘤面临的问题和挑战:第1版[C].北京:人民卫生出版社,2002.283-290.
-
2Harrington DJ,Lessey BA,Rai V,et al.Tenascin is differentially expressed in endometrium and endometriosis[J].J Pathol,1999,187 (2):242-248.
-
3Marks F,Furstenberger G.Cancer chemoprevention through interruption of multistage carcinogenesis.The lesson learnt by comparing mouse skin carcinogenesis and human large bowel cancer[J].Eur J Cancer,2000,36 (3):314-329.
-
4沈悭,朗景和.妇科肿瘤面临的问题和挑战[M].北京:人民卫生出版社,2002:283-290.
-
5Murdoch WJ,Lund SA.Prostaglandin-independent anovulatory mechanism of indomethacin action:inhibition of tumor necrosis factor alpha-induced sheep ovarian cell apoptosis[J].Biol Reprod,1999,61(6):1655-1659.
-
6Ho CC,Yang XW,Lee TL,et al.Activation of p53 signalling in acetylsalicylic acid-induced apoptosis in OC2 human oral cancer cells[J].Eur J Clin Invest.2003,33(10):875-882.
-
7Shao J,Fujiwara T,Kadowaki Y.Overexpression of the wild-type p53 gene inhibits NF-kappaB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells[J].Oncogene,2000,19(6):726-736.
-
8Okamura K,Miyake K,Koshikawa T,et al.Growth fractions of transitional cell carcinomas of the bladder defined by the monoclonal antibody Ki-67[J].J Urol,1990,144(4):875-878.
-
9Berns EM,Foekens JA,van Staveren IL,et al.Oncogene amplification and prognosis in breast cancer:relationship with systernic treatment[J].Gene,1995,159(1):11-18.
-
10Drake JG,Beeker JL.Aspirin-induced inhibition of ovarian tumor cell growth[J].Obstet Gynecol,2002,100(4):677-682.
引证文献3
-
1陈颖,罗剑儒,魏璐,唐良萏.阿司匹林对卵巢癌SKOV3细胞株的增殖和凋亡研究[J].肿瘤基础与临床,2006,19(6):464-467. 被引量：2
-
2张雯琪,杨昌硕,郭虹,赵慧,庄朋伟,张艳军.对乙酰氨基酚对Lewis肺癌荷瘤模型小鼠上皮屏障功能的影响[J].现代药物与临床,2021,36(7):1349-1353.
-
3陈颖,唐良萏.非甾体类抗炎药应用于妇科肿瘤的研究进展[J].实用妇产科杂志,2004,20(1):11-13.
-
1丁岩,陈晓光.基质金属蛋白酶与肿瘤的侵袭和转移[J].哈尔滨商业大学学报（自然科学版）,2002,18(4):373-378. 被引量：3
-
2冯磊光,马学华,张淑杰.奥沙利铂在胃癌细胞侵袭与转移中的作用[J].中国老年学杂志,2003,23(7):431-432. 被引量：1
-
3张琳,王飞,李海涛.基质金属蛋白酶抑制剂的抗肿瘤作用研究[J].解放军药学学报,2004,20(4):262-264. 被引量：1
-
4姜成钢,刘芙蓉,徐惠绵,吴涛,高建.西咪替丁对人胃癌细胞SGC-7901生物学行为的影响[J].中华医学杂志,2006,86(26):1813-1816. 被引量：1
-
5陈晓光.抗肿瘤药物研究策略与方向[J].首都医药,2003,10(22):11-15.
-
6施波,李兰敏,尤胜权,徐世平,韩锐.维A类化合物4-APR抑制肿瘤侵袭、转移的作用[J].药学学报,1997,32(1):33-34.
-
7张中林,刘志苏,孙权.反应停对人肝细胞癌生长侵袭的作用[J].中华实验外科杂志,2005,22(8):933-935. 被引量：8
-
8杨玉琪,李玛琳.人参皂甙的抗肿瘤作用及其机制[J].药学进展,2003,27(5):287-290. 被引量：21
-
9鲁藜,邓华瑜.茶多酚与EGCG对人乳癌细胞株侵袭影响的研究[J].重庆医科大学学报,2004,29(4):441-443. 被引量：4
-
10卢春兰,曾锦荣.过氧化物酶体增殖物激活受体α亚型受体激动剂非诺贝特抗肿瘤作用的研究进展[J].中国预防医学杂志,2014,15(8):765-768.
