两种剂量奥美拉唑治疗复合性溃疡的疗效比较

Clinical and Gastroscopic Observations on the Therapeutic Effects of Two Different Dosages of Omeprazole in Patients with Composite Ulcers

目的 :评价两种剂量奥美拉唑治疗复合性溃疡的疗效及安全性。方法 :甲组 ,3 2例复合性溃疡患者口服奥美拉唑 4 0mg ;乙组 ,选取条件相似的患者 3 2例 ,日服奥美拉唑 2 0mg。疗程均为 6周。治疗期间 ,第 1,3 ,6周应用内镜观察溃疡愈合情况。结果 :两种剂量奥美拉唑治疗复合性溃疡中远期效果差异无显著性 ( P>0 .0 5 ) ,近期效果差异有显著性 (P <0 .0 5 )。不良反应两者比较差异无显著性 (P >0 .0 5 )。结论 :两种剂量奥美拉唑治疗复合性溃疡中远期效果相当 ,近期效果尤其是患者的主观感受方面日服 4 0mg优于日服 2

Objective:To evaluate the curative effect and safety rate of two different dosages of omeprazole in patients with composite ulcers with the use of gastroscopy. Methods:Each of the 32 patients with compoosite ulcers (group A) was given a single oral dose of 40mg of omeprazole qd, while a daily dose of 20mg of omeprazole was taken by each of the 32 patients in similar conditions (group B). The course of medication lasted 6 weeks. During this period, gastroscopy was used to observe the healing condition of the ulcers at the lst, 3rd and 6th weeks. Results:The differences were not significant between the intermediate and remote effects of the two dosages of omeprazole in the treatment of composite ulcers (P>0.05) However, the difference was significant between the short term effects (P<0.05). The differences between the adverse reactions of the two dosages were insignificant (P>0.05). Conclusion: The intermediate and remote effects of the two different dosages of omeprazole were essentially similar in the treatment of composite ulcers.A daily dose of 40mg was found to be superior to the 20 mg dose for short term effects, especially in consideration of the subjective feelings of the patients.