前列地尔治疗糖尿病性周围神经病变20例

Treatment of 20 Cases of Peripheral Diabetic Neuropathy with Alprostadil

目的 :观察前列地尔治疗糖尿病性周围神经病变的疗效。方法 :糖尿病性周围神经病变患者 4 0例 ,随机分为两组 ,治疗组 2 0例 ,给予前列地尔 10 μg,静脉滴注 ,qd ,2 0d为 1个疗程 ,对照组 2 0例 ,给予丹参注射液 2 0mL ,用法和疗程同治疗组 ,分别于治疗前后测定神经传导速度、血浆粘度、血小板聚集。结果 :治疗组疗效优于对照组 ( P <0 .0 1)。结论 :前列地尔是治疗糖尿病性周围神经病变较理想的药物。

Objective: To observe the therapeutic effects of alprostadil (PGE 1) on peripheral diabetic neuropathy. Methods: 40 diabetics with peripheral neuropathy were randomly divided into two groups treated with Alprostadil (PGE 1) and Salvia miltiorrhiza (SM), respectively. Patients in the test group were given each a daily dose of 10 μg of PGE 1, by intravenous instillation for 20 consecutive days. Salvia miltiorrhiza was used instead for patients of the control group. Conduction velocity of the peripheral nerve, plasma viscosity and platelet aggregation were determined before and after the treatment. Results: The effects of PGE 1 are superior to those of SM (P<0.01). Conclusion:PGE 1 is a relatively ideal remedy for the treatiment of peripheral diabetic neuropathy.