摘要
目的 :评价硫酸依替米星对感染性疾病的疗效及不良反应。方法 :用硫酸依替米星 2 0 0mg溶于 10 0mL灭菌溶液中静脉滴注 ,bid ,疗程 5~ 10d ,进行多中心开放试验。结果 :感染性疾病 42 1例 ,单用药组 35 8例 ,治愈率6 6 .2 % ,总有效率 91.1% ,细菌阳性率 80 .4% ,细菌阴转率 90 .6 % ,细菌清除率 92 .6 %。其中对呼吸道、泌尿道、消化道、外科感染的治愈率、总有效率分别是 5 0 .9% ,83 .3 % ;75 .0 % ,94.8% ;75 .9% ,86 .2 % ;73 .6 % ,98.1%。联合用药组 6 3例 ,治愈率、总有效率、细菌阳性率、细菌阴转率和细菌清除率分别为 42 .9% ,81.0 % ,76 .2 % ,81.3 %和 81.6 %。 10例出现不良反应 ,不良反应总发生率 2 .8%。其中 3例因不良反应严重而停药。结论 :硫酸依替米星具有疗效高。
Objective:To assess the effects and side effects of etimicin injection in the treatment of bacterial infectious diseases. Methods:Multicentral open clinical trials were performed. Results:In patients treated by etimicin only, the curative and effective rates as well as the bacterial eradication rates were 66.20%, 91.06% and 91.2%, respectively, while the curative and effective rates for those with infections of the respiratory, urinary and digestive tracts as well as infections caused by surgery were 50.85% versus 83.25%, 75.00% versus 94.77%, 75.87% versus 86.21% and 75.87% versus 86.21%, respectively. In patients treated by use of etimicin in combination with the other antimicrobial agents, the curative and effective rates as well as the bacterial eadication rate were 42.86%, 80.95% and 81.6%, respectively. The incidence of side effects was 2.8%. Conclusion: Etimicin is a highly effective drug for treating the infectious diseases with low toxicity.
出处
《医药导报》
CAS
2001年第11期693-694,共2页
Herald of Medicine