摘要
利用连锁不平衡理论 ,人类遗传学家已能把影响人类疾病的质量基因定位在小至 1cM区域内 ,有些基因已被克隆出来。罗泽伟等进一步发展统计分析方法检测及估算分子标记与QTL之间的连锁不平衡系数 ,从而提出了人类复杂遗传病高解析度基因定位的理论策略。以此为基础 ,进一步探讨了供试群体在双亲基因频率存在差异时检测QTL和检测QTL互作的方法 ,给出了有关的理论结果。
Some genes controlling human diseases have been located on the regions less than 1 cM using linkage disequilibrium, and a few of them have been cloned. Z. W. Luo developed a method that can detect and estimate the coefficient of linkage disequilibrium between a marker locus and quantitative trait locus (QTL), and raised the theoretical strategies for high resolution mapping of complex genetic disorders in humans. Based on the data mentioned above, a method for linkage test between a marker locus and QTL was set up, and a method for linkage test between two marker loci and epistatic QTL was suggested for the first time.
关键词
复杂遗传病
连锁不平衡
基因定位
QTL分析
complex genetic diseases
linkage disequilibrium
gene mapping
QTL analysis
