缺糖转铁蛋白对酒精性肝病的诊断意义

Serum carbohydrate-deficient transferrin determination in the diagnosis of alco holic liver disease

目的 评价缺糖转铁蛋白 (CDT)对酒精性肝病的诊断价值。方法 选择 76例酒精性肝病 ,5 5例嗜酒者 ,3 2例非酒精性肝病和 2 7例健康者 ,分别检测谷氨酰转肽酶 (GGT)等肝功能指标和CDT。结果 酒精性肝病组CDT阳性率为 93 .4 % ;CDT诊断酒精性肝病的灵敏度为 93 .4 % ,特异性为71.9% ,诊断价值高于GGT、丙氨酸转氨酶 (ALT)和天冬氨酸转氨酶 (AST)。结论 CDT是诊断酒精性肝病较理想的指标。

Objective The aim of the study is to asses s the reliability of carbohydrate-deficient transferrin(CDT) in the diagnosis o f alcoholic liver disease(ALD). Methods Based on the diagnostic criteria for alcoholic liver di sease formulated by Chinese Medical Association in Nanjing 1995, seventy-six al coholic liver disease patients, 55 cases of alcoholism, 32 nonalcoholic liver d isease patients(NALD), and 27 healthy subjects as controls were studied. Serum C D T was assayed by isoelectric focusing, immunofixation, and Comassie blue stainin g. ALT, AST, and GGT were also examined. Results The positive rate of CDT in ALD is (93.4%)(71/76), high er than that in alcoholisms(52.7%,29/55,P<(0.001)), in NALD(9.4%,3/32,P (<0.001)), and in healthy controls(0). The sensitivity and specificity of CDT for ALD is 93.4% and 71.9% (respectively.) Conclusion CDT may of help in diagnosing alcoholic liver disease.