过氧化物酶体增殖物活化受体与促炎介质(综述)

Peroxisome proliferator-activated receptors and proinflammatory mediators (A review)

近年来发现 ,核受体超家族成员———过氧化物酶体增殖物活化受体 (peroxisomeproliferator-activatedreceptors ,PPARs)是一组转录因子 ,它与某些促炎介质 ,如 :白三烯B4 及肿瘤坏死因子等有密切关系 ,这类受体与相应配体结合活化后 ,将有助于感染性疾病的治疗。对PPARs的结构和功能 ,配体的一般特性以及PPARα、PPARγ对促炎介质的调节作一综述。

Peroxisome proliferator-activated receptors (PPARs) are a group of transcription factors belonging to the nuclear receptor superfamily. Recently, they have been found related to proinflammatory mediators. Some studies in vivo or in vitro suggested that PPAR could act as regulators of lipid inflammatory mediators, such as leukotriene B4 through arachidonic acid metabolism; its agonists might inhibit the production of inflammatory cytokines, such as TNFα. Thus, PPAR ligands may be valuable in the treatment of infectious diseases. In this review, properties of the PPAR isotypes were described and their significant effects on regulation of proinflammatory mediators were discussed.